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Gilead Sciences concurrent remdesivir
TTFields application together with <t>remdesivir</t> is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.
Concurrent Remdesivir, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 15565 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/concurrent+remdesivir/VEKLURY/pmc10716356-186-22-23
Average 99 stars, based on 15565 article reviews
concurrent remdesivir - by Bioz Stars, 2026-10
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1) Product Images from "Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study"

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study

Journal: Frontiers in Microbiology

doi: 10.3389/fmicb.2023.1296558

TTFields application together with remdesivir is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.
Figure Legend Snippet: TTFields application together with remdesivir is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.

Techniques Used: In Vitro, Infection, Quantitative RT-PCR, Fluorescence, Staining, Comparison

Baseline characteristics and treatment details.
Figure Legend Snippet: Baseline characteristics and treatment details.

Techniques Used:

Effectiveness endpoints.
Figure Legend Snippet: Effectiveness endpoints.

Techniques Used:

Ordinal score for clinical improvement (OSCI) at specific time points, no. (%, [95% CI]).
Figure Legend Snippet: Ordinal score for clinical improvement (OSCI) at specific time points, no. (%, [95% CI]).

Techniques Used:

Related Articles

In Vitro:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Infection:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Quantitative RT-PCR:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Fluorescence:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Staining:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Comparison:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.

Coagulation:

Article Title: Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants initiated within 48 h of admission were more common in those who received dexamethasone than in those who did not (remdesivir 43% versus 13%; anticoagulants 46% versus 10%, respectively).

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study
Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Article Title: Early initiation of corticosteroids in patients hospitalized with COVID-19 not requiring intensive respiratory support: cohort study
Article Snippet: Concurrent remdesivir and prophylactic anticoagulants were more common in those who received corticosteroids (remdesivir 39% vs. 13%; anticoagulants 33% vs. 21%) than in those who did not.

Article Title: Case Series of Patients with Coronavirus Disease 2019 Pneumonia Treated with Hydroxychloroquine
Article Snippet: Of the 27 patients, 18 (66%) received concurrent AZM, 8 (30%) received a concurrent corticosteroid, 3 (11%) received concurrent favipiravir, 2 (7%) received concurrent lopinavir and ritonavir, 2 (7%) received concurrent tocilizumab, and 1 (4%) received concurrent remdesivir.

Article Title: JAK -inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis
Article Snippet: Fifth, one large study gave concurrent remdesivir confounding our evaluation of baricitinib.



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TTFields application together with <t>remdesivir</t> is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.
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TTFields application together with <t>remdesivir</t> is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.
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TTFields application together with remdesivir is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.

Journal: Frontiers in Microbiology

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study

doi: 10.3389/fmicb.2023.1296558

Figure Lengend Snippet: TTFields application together with remdesivir is beneficial in vitro . TTFields were applied for 48 h, alone or concomitantly with 0.011 or 0.023 μM remdesivir, to MRC-5 cells that were infected during the first 3 h of treatment with HCoV-229E (MOI = 0.01). The intracellular viral amount was examined by RT-qPCR (A) and by fluorescence detection of dsRNA with green staining, and cellular nuclei imaged with blue DAPI (x20 magnification) (B) , and the extracellular viral amount was examined by RT-qPCR (C) . MOI, multiplicity of infection; dsRNA, double stranded RNA; RQ, relative quantification. Values are mean ± SD. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 relative to control; Sidak’s multiple comparison.

Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Techniques: In Vitro, Infection, Quantitative RT-PCR, Fluorescence, Staining, Comparison

Baseline characteristics and treatment details.

Journal: Frontiers in Microbiology

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study

doi: 10.3389/fmicb.2023.1296558

Figure Lengend Snippet: Baseline characteristics and treatment details.

Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Techniques:

Effectiveness endpoints.

Journal: Frontiers in Microbiology

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study

doi: 10.3389/fmicb.2023.1296558

Figure Lengend Snippet: Effectiveness endpoints.

Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Techniques:

Ordinal score for clinical improvement (OSCI) at specific time points, no. (%, [95% CI]).

Journal: Frontiers in Microbiology

Article Title: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro , and safety for application to COVID-19 patients in a pilot clinical study

doi: 10.3389/fmicb.2023.1296558

Figure Lengend Snippet: Ordinal score for clinical improvement (OSCI) at specific time points, no. (%, [95% CI]).

Article Snippet: Treatment duration and usage were higher for patients treated with TTFields alone (4 days and 67.2%, respectively) relative to patients treated with concurrent remdesivir (2 days and 44.8%, respectively), due to two patients from the latter group who decided to discontinue early.

Techniques: